Search results for "Hyperbranched polyglycerol"
showing 3 items of 3 documents
Rapid Access to Polyfunctional Lipids with Complex Architecture via Oxyanionic Ring-Opening Polymerization
2011
Polymer-coated liposomes, particularly poly(ethylene glycol) (PEG)-substituted liposomes, have emerged as long-circulating carrier systems for drug delivery and diagnostic purposes. A rapid synthesis of three different types of multifunctional lipids with structurally diverse hydrophilic, polyether-based architectures via one- or two-pot approaches is described. Architectural variation is achieved by the combination of different oxyanionic polymerization strategies and various glycidyl ether building units. Branched polyglycerol lipids have been prepared via cholesterol- or 1,2-bis-n-alkyl glyceryl ether-initiated, oxyanionic ring-opening polymerization (ROP) of protected glycidyl ethers an…
Novel Multifunctional Polymeric Photoinitiators and Photo-Coinitiators Derived from Hyperbranched Polyglycerol
2007
A new class of hyperbranched PPIs and PPCs have been prepared. The introduction of compatibilizing groups such as MEEA or trimethylacetate enhanced their solubility in radiation-curable formulations and led to an improved photoactivity compared with the corresponding MPI and MPC. Although the molecular weights of the subject PPIs and PPCs exceeded 800 g mol -1 , the viscosities of the radiation-curable formulations were still suitable for inkjet application. The combination of high photoactivity, low viscosity, and low extract-ability after curing rendered the resulting hyperbranched PPIs and PPCs attractive as components in the inkjet ink for inkjet printing, e.g., in food packaging.
Multifunctional Poly(ethylene glycol)s
2011
In the rapidly evolving multidisciplinary field of polymer therapeutics, tailored polymer structures represent the key constituent to explore and harvest the potential of bioactive macromolecular hybrid structures. In light of the recent developments for anticancer drug conjugates, multifunctional polymers are becoming ever more relevant as drug carriers. However, the potentially best suited polymer, poly(ethylene glycol) (PEG), is unfavorable owing to its limited functionality. Therefore, multifunctional linear copolymers (mf-PEGs) based on ethylene oxide (EO) and appropriate epoxide comonomers are attracting increased attention. Precisely engineered via living anionic polymerization and d…